Honestly, i don't know enough about running a store to know what I would do.
If the store is a part of a big company (as I think you mean), then the answer is probably yes (unless my superiors told me otherwise), because even if I thought it was going to be problem, I wouldn't want to risk a lawsuit.
If you're talking about a store completely owned by me, I probably still would because of ethical reasons (as I believe strongly in equal opportunity), but if the consequences would be such that I'd be losing a lot of customers, my resolve would probably dwindle.