Uncharted 4 will NOT have pre-rendered cut-scenes.

[Baryonyx]

How is pre-rendered more realistic?
You go from gameplatt graphics into a pixar animation and back to gameplay graphics. 
If the game graphics are good, why should real-time cutscenes bother you? 
it also improves the concistency, loading as well as smaller game file sizes. 
What we have seen on Uncharted 4 and The order and the cutscenes have looked far better then previous games and it is real-time. 
It's better to cut pre-rendered cutscenes out of the picture and let real-time cutscenes take the stage and advance with the time instead of holding it back.