Too many to name (I luv video games and being in touch with my feminine side doesn't help either) . But I'll just mention some I played recently:
Super Mario 3D Land - Put the "Super" back in Super Mario again for me. The music, the freedom, the power ups... Just AWESOME!
Legend of Zelda: Ocarina of Time 3D: Nostalgia personified! The Music and the Epic quest made me feel like I was a 12 year old kid playing it again!