Off the top of my head, the end of Paper Mario: The Thousand Year Door. It's totally silly, because it's a colorful game with silly little sprites, but something about that last boss battle was really uplifting and touching to me. In fact I might even say that I was more moved BECAUSE it was done with sprites. I find I connect more emotionally with cartoons/puppetry/etc. than with real actors or realistic cutscenes. Maybe it's something about the innocence, I don't know.
Currently playing:
Bloodbath Paddy Wagon Ultra 9







