Quite a few old PC Games. In no particular order:
Battle Isle and it's spinoffs (Incubation, History Line)
Panzer General and it's Spinoffs (Fantasy General, Pacific Admiral, People's General)
Magic Carpet (would also work well on a Console)
Theme Park/Hospital
Master of Orion
Ceasar and it's Spinoffs (Zeus, Cildren of the Nile)
Might & Magic (in the original Universe, not the High Fantasy Ubicrap Universe)
Wizardry (I want to use my Wizardry 8 Final save someday!)
And a few Console/Arcade Titles:
BC Kid (Bonk)
Bomberman (in 2D!)
2D Brawlers (Double Dragon, Bare Knuckles (Streets of Rage), Final Fight...)
F-Zero