I don't see why there's so many no's. I mean, Capcom couldn't make another Ocarina of Time, but if they used combat elements from DMC, added some dark stuff in there like Resident Evil, and maybe even make a great online. I say they could, but it would take time and money to do so.
XBOX ONE/Wii U/3DS/PC
RIP Iwata 12/6/1959-7/11/2015
Thanks for all the great memories!