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It has always amazed me that Rockstar has not used its game engine for more games. They made Red Dead Redemption with the same engine as GTA IV (is Red Dead Revolver done with GTA III engine?). They made the Zombie DLC with the same engine.
Games genres that could be made with the GTA V engine:
WRPG (BioShock)
Racing game (open world Midnight Club, Smuggler's run)
Sports games (Olympic games, NBA, WWE, Table tennis)
Sim-game (Bully)
Shooter (Borderlands)
Hunting simulator
Strategy game (Civilization, XCOM)
Fighting game (The Warriors)
Star Wars-game
LA-noire sequel
Manhunt sequel
Max Payne sequel
Oni sequel
State of Emergency sequel