The last level of Hard Corps: Uprising was ridiculous. It is very rare that I give up on a game but I got so pissed off at all of the ridiculous random "timing" scenarios it kept throwing at you in that 1 level that I never beat it. I uninstalled it and have not played it since it pissed me off so bad. It was a great game otherwise too.
When Max Payne 3 came out I started it on the hardest difficulty out of the box that it had and there were some sections in it where you fight sheriffs in office cubicles with automatic weapons that were INSANE. Died prob 100 times trying to figure out how to pass it. The frustration in that game was rewarding though. While not quite as good as 2, it is an underrated game that everyone should play.
But hands down must frustrating of all... Ninja Gaiden 2 on Xbox 360. If they hadn't remade the sigma versions of those games I bet people would not have liked them. the original 360 versions were ridiculous.
