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But are they any good? 

I played The Binding of Isaac and I was bored before getting past the first floor.  Imo it's yet another indie developer trying to push out an artistic graphical style with rather garbage gameplay.  Just feels bland and boring running from room to room killing everything within, collecting the power ups, and then moving on to the next room.  I got to floor three before I couldn't take it anymore and just shut the game off.

I know the devs in The Binding of Isaac are trying to give some semblance of randomization and replayability by making it rogue like style, but if I wanted to play a good game similar to this style, minus the randomness, then there have been a lot of games that I could play.  Smash TV, Total Carnage, and more recently, Dead Nation are some of the few that aren't borefests.