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I would have to go with RE4 over The Last of Us. There were just so many great moments in RE4 and when I think about comparing The Last of Us, I think about the scenarios that are similar but done better in RE4. The defend the cabin sequence on RE4 was so much better than the small shack Ellie defends. The sniper section to protect Ashley in RE4 was more tense than the sniper section on Last of Us. I also felt like RE4 had better variety, boss battles, etc.

If you guys liked either of these games you really should pick up The Evil Within. It feels like a combination of RE4 and The Last of Us.