I thought about the comparison between the two when I was playing through TLoU and while TLoU is brillant, it didn't manage to overthrow Resident Evil 4 in my heart.
As for fights, Joel would beat Leon in a hand to hand combat but Leon has a better arsenal at his disposal if weapons are involved. Ellie would obviously have the upper hand on Ashley. Ada would win against Tess (although I love Tess) because Ada is a fucking bad ass.
For the enemies, Regenerators are way scarier than clickers. Also, I never thought of bloaters as scary since they're slow and never caused me that much trouble.
Signature goes here!