GTAIV is looking like a contender however I think it will have a Halo 3-esque reception.
Brawl probably won't be a contender due to its style and the fact that it wasn't actually perfectly pulled off.
MGS4 won't be a contender as its too heavy and too niche, a stealth game with a deep plot just won't get it in my opinion. Gears 2 might be a contender but I just don't think its going to live up to its predecessor.
Resistance 2 probably won't be a contender due to the fact that Resistance 1 wasn't actually a blow your socks off good game.
Little Big Planet I just don't feel is big enough, may have a shot however if its pulled off really well.
WiiFit I feel has the best chance of currently known games but it really depends on how western reviewers accept the idea of a game based on fitness.
