Since there's no restrictions in the fight. MC. By pure help numbers. Samus wants no help under normal situations. That mean only her power suit abilities. Chief has too many functions and vehicles at his disposable. And if you really want to stretch it. Call in armies. If you also put in game limitations. Samus' suit can't recharge on its own. The only way for her to win. Is to shut down his suit. And force Hand to Hand combat.
It depends on what equipment each one has at the time. If MC has Armor Lock worst case for Samus. If Samus has Phazon Suit, worse cast for MC.







