Bman54 on 27 September 2014
If we're talking fully upgraded Samus, the she could easily win. It doesn't really take much to kill Master Chief in the game, at least when you're playing as him. Samus has way more in her arsenal: the ScrewAttack, morphball, super speed (after a little while of running), missiles, power bomb, various types of beam weapons, grappling hook, she's more acrobatic. I'd say it's an easy win for her.
