Ucell on 05 June 2014
Since Chicago has recently been done in Watch Dogs, I think its out of the question. Also it would be too similar to LC but without any of the recognised landmarks of NYC.
Los Santos is just not possible.
San Fierro hasn't been featured since San Andreas but I think its too small and not one of USA's biggest cities. Maybe in a handheld spinoff it would make sense.
Vice City wouldn't make much sense if its set in the current decade because it will lose the atmospheric and wonderful 80's vibe.
So that leaves us with Las Venturas. I think the casinos and mafias would open new gameplay avenues for GTA VI. So I think that would be the city featured in GTA VI.
