1. Virginia (Wild ARMs 3)
2. The Boss (Metal Gear Solid 3)
3. Kyoko (Dangan Ronpa: Trigger Happy Havoc)
4. Tifa (Final Fantasy VII)
5. Zoe (SSX)
6. Nina (Tekken)
7. Chloe (Uncharted)
8. Nariko (Heavenly Sword)
9. Maia (Summoner 2)
10. Carmelita (Sly Cooper)
I actually put some thought into this, and into the ordering. Some are one-off characters that absolutely blew me away in their respective games. Others are recurring characters who I either play every time I pick up a new game in the series; or enjoy seeing every time I pick up a new game in the series.
I think it's safe to say they're all kick-ass, though. No damsals in distress here.