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Unless it's Call of Duty I don't think you can say any game has actually defined last gen. You can only list games that you think may have been popular but that doesn't necessarily mean those games defined what the gen was.

Last gen was either military FPS titles because of Call of Duty, or cinematic experiences which one game can't really take the credit, but I'd guess if so, then devs may have been inspired by Uncharted. .

If you mean definied as in my favorite titles of last gen,, which I don't really think defined much of anything.

Lords of Shadow series
XCOM Enemy Unknown/Enemy Within
Uncharted series
Infamous 2
Heavy Rain
Twisted Metal
Demon's Souls

Just to name a few.