It's an uphill battle for nintendo in the west. The competition is not only entrenched it's expanding its potential base with marvel and star wars, and without the 3ds to act as a safety net for the first half year it could flounder out of the gates. Especially when you consider that skylanders and infinity don't need wii u to succeed but are still going to be competing directly with nintendo on their own hardware.
Japan is a different story, the playing field is even there as neither infinity or skylanders have been introduced there, so nintendo could carve their niche in the homeland.