Umbrella Chronicles was actually really hard (if you went for the good ratings) however I eventually became very skilled and it became a lot easier. RE4 on professional was brutal too. Still, nothing 'impossible' comes to mind.
Although I know it's not what the OP meant, No More Heroes was very brutal even though it was cell-shaded, because not only did you kill people, but you killed those who surrendered, old ladies, and even (watch out, spoiler!) your own sister. All with a smile on your face. That's not very moralistic, don't you agree?
I drink your milkshake.







