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So, if both casual and hardcore will be pleased...

I'm guessing maybe:

A new Punch-Out
A new 1080 Snowboarding
Animal Crossing (guaranteed @ E3)
Kirby (guaranteed @ E3)
Disaster (guaranteed @ E3)
Kid Icarus
One or two new IP's.

The first two will get hardcore gamers salivating, and both will appeal to the pick-up-and-play aspect of the Wii for casual gamers.