Recent examples from my most favorite genre:
- Rosangela and Lauren Blackwell (the last game of the series which is named after their female protagonists will be released soon)
- Nicole Collard (Broken Sword - first part of the fifth game was released recently)
- Vella (Broken Age - first part of the game was released recently)
- Zoë Castillo and April Ryan (The Longest Journey/Dreamfall/Chapters series - new game is in the works, release expected this year)
- Kate Walker (Syberia series - new game is in the works, release probably next year)
- Ivo (The Book of Unwritten Tales series - new game announced two weeks ago)
- Lilly (Lilly Looking Through - one of the most charming releases of 2013)
- Sadja (Memoria - in my opinion the best p&c adventure game of 2013)
- Erica Reed (Cognition - according to fellow genre fans the best adventure game of 2013)
- Susan Ashworth (The Cat Lady, according to reviewers one of the most original p&c adventure games of 2013)
- Kaitlin Greenbriar (Gone Home, according to reviewers the best graphic adventure game of 2013)
- Nina Kalenkow and Sam Peters (Secret Files series)
- Fay (A New Beginning)
- Edna & Lili (Edna & Harvey series)
- Samantha Everett (Jane Jensen's Gray Matter)
There's also a ton of Nancy Drew games (don't know much about this series, never played one)
"Historic" genre examples:
Zanthia (The Legend of Kyrandia: Hand of Fate) => side note: I wished someone would revive this series
Laverne (Maniac Mansion: Day of the Tentacle)
Valanice and Rosella (King's Quest 7)
Laura Bow (The Colonel's Bequest)
Elaine Marley (Monkey Island series - not a playable character though)
Consoles: Lara, Samus, Joanna Dark, Jade (BG&E), one of the Heavy Rain characters, the Beyond: Two Souls character etc.
