In-breeding is not really a problem - animal breeders do this all the time.
The entire world population of cheetas (highly endangered) are believed to have been wiped out to only 2 closly related individuals but these animals are very healthy ones with no bad recessive disorders and if people stopped killing them and destroying their environment they will eventually recover to a healthy population.
Expression of minor recessive genetic disorders is common color blindness is just one of thousands of minor ones which are very common. Late onset ones like parkinsons are rare. Any severe recessive disorders are hidden by instant death of the sex cells even before they even get to the emberyo stage of development or if not shortly afterwards. If it were not for this constant gene filtering going on life could not exist as it does.
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