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Some franchises from the DS/3DS would make a great transition to Wii U. I would be all over Professor Layton U, the story and setting could be on a grander scale with the better hardware, whislt retaining the charming puzzles on the touchscreen. A hotel dusk game would obviously work well too.
Also im surprised more strategy games havent been on Wii U, the set up is there to make a great strategy game like Advance/Battalion Wars for example. Fatal frame, Minecraft, Monkey Ball are all games that could make interesting use of the second screen.