If you'd like to know what game I enjoyed the most, it's Xenoblade.
But as for which game I think was the most influential, I'd go with Wii Sports. Minecraft is pretty close, too, but I think its influence will be much more strongly felt in the eighth generation.
3DS Friend Code: 0645 - 5827 - 5788
WayForward Kickstarter is best kickstarter: http://www.kickstarter.com/projects/1236620800/shantae-half-genie-hero