I don't know how well the Wii-mote is implimented in games. I hear people talking about MP3, but I have yet to try it out. I did, however, play Resident Evil: UC two weeks ago and I dreaded the response time of my movement with the on screen cursor. Aiming felt like the world around me was moving in slow motion while I was moving in regular speed. When it comes to the Wii-mote, I dislike the button config and the lack of buttons when compared to the mouse/keyboard and when it comes to the motion sensor, I couldn't care less and I think that it hurts my wrists and elbows so I would rather have a button compared to having to throw my arm around trying to do the same thing.
When it comes to a regular controller verses a mouse, I feel like I'm suddenly gimped when I try to use a controller for a shooter. I can get used to it after time, but I feel much more comfortable when I'm using a keyboard and mouse.
Anyway, mouse and keyboard is what I like when comparing something like a FPS on a console and PC.
