I'm going to limit my top 10 to one game per franchise. Otherwise, it will all be Mass Effect, Uncharted, and Halo.
1. Mass Effect
2. Uncharted 2: Among Thieves
3. Journey
4. Halo: Reach
5. Fallout 3
6. BioShock
7. Red Dead Redemption
8. Assassin's Creed II
9. Super Mario Galaxy
10. Batman: Arkham City