So after this week's impressive Vita sales in Japan, I decided to take a look at what could be the biggest upcoming system movers (which have been announced).
God Eater 2: Pretty much goes without mention. It had a solid playerbase on PSP which has only grown, it has a Vita hardware bundle, and it's going to attract the hunting game crowd, especially those who didn't buy MH4 or were disappointed (it's decent but no MHP3, and online is an absolute mess).
Love Live: This is going to be huge. Ever since the anime this IP has attracted an enormous idol cult following. The type of people who would burn hundreds of dollars on just digital cards. These people will be buying Vitas, and probably all 3 versions of the game at once. This is another idolmaster. Another season of the anime will be pushing even more sales.
Kantai Collection: This is another one with enormous potential. The difference here is that, as a social game, the crowd is going to be extremely fickle. Kancolle is very popular right now, and still growing. They just opened a Kancolle collaboration cafe and there was a huge line just to get in (and pay exorbitant amounts for themed dishes). The question is whether that popularity will still be going when the Vita game comes out. If it does, expect circa last year Puzzle&Dragons level of craziness. If not, it won't make a huge impact.
Honorable mention goes to FFXHD. But the above 3 should make a bigger impact than this.