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I would have said asymmetrical for sure before using the Wii U Pro controller, but now I have to say Nintendo's alternative Symmetrical setup is by far the best for FPS's, while assymetrical is still my favorite for action/adventure games which have you using the face buttons more often. IMO, the placement of the right stick doesn't matter too much, but for optimum comfort the left stick has to be higher up on the controller. My left thumb starts to feel a bit strained when using sticks that are placed too low.

That said, I find the Dualshock setup to be the best for games that use the D-pad for primary control, so...