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ishiki said:

The thing is I'm a PC gamer who typically dislikes console shooters, and I'm going to disagree, The survival mechanics and location based damage with takedowns dependent on the location of the shot as well as are far more interesting than anything uncharted does which just sends waves after waves of brainless enemies. IMO. And the shooting from a different axis as you use the laser pointer compared to a reticule feels different and interesting.

RE5 has better in shooting mechanics, and with awesome co-op. But it has less atmosphere (not saying RE4 has a lot), is pretty unplayable in single player due to the horrid AI mechanics.

Location based damage actually wasn't always consistent.  You could do the same amount of head shots or body shots to take down an enemy, or if the weapon had the critical hit ability, sometimes enemies would die in a single headshot.  So only the abilities made a difference in damage if you shot them in the head.

And unless it was Mercenary mode in Resident Evil 4, while special melee attacks looked cool, you had enough ammo that you didn't really have the need to shoot them in the shoulder or the leg in order to have to do a special melee.  In Resident Evil 5, it was actually really useful because it allowed you to conserve much needed ammo as it didn't grow on trees.