Wario Land: Shake It for Wii. Gorgeous 2D hand-drawn goodness. An excerpt from Wikipedia:
"Over 2,000 frames were drawn to animate over 200 actions for Wario alone; over 6,000 frames were drawn for all enemy characters, including those that were removed from the final game. All the game's backgrounds and scenery were also hand-drawn. Program director Koichi Yagi stated that clever programming techniques were required to efficiently store and handle both the non-repeating backgrounds and thousands of character frames in the Wii console memory during gameplay."







