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Super Metroid is great for speed-running. In fact most Metroid games work well.
Sonic the Hedgehog is made for speed-running. Just keep running!

2D Mario also works very well. It really shows in many areas that the designers considered speed-runners when they made the levels.

Lastly, Donkey Kong Country (Returns) is another must-have for speed-runners. Hard as hell but very satisfactory.