If Iwata can't get some high profile games out this holiday, and is unable to sell Wii U and turn a profit, it's simply time to go. But replacing him would be hard! I'd like to see someone else from inside Nintendo take over, but someone younger (40-ish) whom understands Nintendo.
I'm on Twitter @DanneSandin!
Furthermore, I think VGChartz should add a "Like"-button.