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For me, there are quite a few games that have done that.

-Mass Effect (the first one really, #2 was a little emotional, 3, the ending ruined what was turning out to be a killer in the last of the series).
-KoTOR
-Dreamfall: The Longest Journey
-Dragon Age: Origins
-Vampire; The Masquerade-Bloodlines
-Baldur's Gate
-Neverwinter Nights
But this one game really stands out, "Planescape: Torment"