Professor Layton and the Unwound Future's ending was a tearjerker.
BioShock Infinite made me really sad as soon as it ended, it was a magnificent experience and I didn't want it to end.
The fall of The Kingdom of Zeal, among other things, were really depressing in Chrono Trigger.
To The Moon was also a really sad game if you think about what ACTUALLY happened.
Mother 3 was really emotional and depressing.







