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BloodyRain said:

I mean is there any changes to like the gameplay? Is it still going from gym to gym then the league. Any other big changes to the games.

There have been major changes to many gameplay elements. You still gather badges from the Gym's and you still defeat the Elite Four, but there are many twists in turns whilst making your way through the game. If you want to get back into the series I suggest jumping right into Pokemon Black2/White2. These games are practically perfect. (And they include many old and new Pokemon to catch from the beginning.)