Milked Games. Which ones should stay, Which ones should take a break?

[Kresnik]

Any that are showing signs of dipped quality/lacking ideas in their latest releases.

So from your list: God of War; Sonic; Assassin's Creed; Fable; 2D Mario; Ratchet; Final Fantasy would be the ones I'd single out. We'll be finding out if Gears of War will be joining them shortly.

That said, as a fan of Ratchet & a reconverted fan of Final Fantasy (I don't care what anyone says, XIII-2 was enjoyable), I wouldn't want either of those series to stop. And I would imagine it's the same for fans of any of these series, so I wouldn't necessarily advocate for any of them taking a break.

All I would say is, make sure the developers take caution when developing future instalments. Don't play it too safe (Mario; Call of Duty); but don't go so far in a different direction that you make something no-one wants, either (Fable; Ratchet).