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Autonomous vehicles.
(Safety)

Average lifespan of 200 years.
(Overpopulation)

The completion of M-Theory.

"Free" energy through magnetic generators/engines
(The end of the gas monopolization for fueling vehicles)

The movement toward working from home versus needing office space.
(Less social interaction at work)

World War III
(Doom's day scenario, 1% survives.)