1. Mass Effect
2. Uncharted
3. Assassin's Creed
4. Souls Series
5. Valkyria Chronicles
Though there are a ton of note worthy new IP's this gen: Dragon Age, Borderlands, Portal, Batman Arkham games, thatgamecompany games, Resistance, Infamous, Prototype, Mirror's Edge, Heavy Rain, Vanquish, Binary Domain, Catherine, Gravity Daze, Dishonored and Chivalry: Medieval Warfare (more people need to play this) are what i can name off the top of my head + more that I have yet to play but know are top notch like Gears of War. Ni no Kuni would probably take the number one spot right now if it was a series, Having so much fun right now and I'm only 10 hrs in.