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System Shock II. I played it before they patched in options to turn down/off weapon degradation and enemy respawn and although I didn't give up, I cheated to reach the end. As far as I'm concerned, I gave up. I'll return to it someday, as murderously hard as it is. Other than SSII, I have only given up on hard games that are cheap or poorly programed/designed such as Battletoads or Ninja Gaiden NES.