At the moment I would have to say StarWars Force Unleashed. It looks awesome.
Resistance2: Close second but lacks the StarWars starpower
MGS4: Takes itself too seriously
FFXIII: Japano RPGs ierk
Gran Tourismo: Beautiful but not my genre.
Killzone2: Looks great but I played Killzone1
Anyway it will be a great year. I hope I can forget the PS3 autumn that didn't have ONE decent game