That was the first thing I thought about when I read the thread title, and there the picture was when I opened it. The tentacle monster in Half-life was extremely nerve racking, especially since I had 13 health left and was sneaking around back and forth figuring out how to get the incinerator to work.
Regenerating health has killed all tension from fps games, and the sheer relief of finally finding a new health station is sorely missed.
Stalker is a close second. One of the missions has you explore a dark underground lab with all kinds of paranormal activity.







