Things i would love to see at E3 this year are:
New Sonic game that uses the sonic generations engine for the 3DS.
Resident evil downfall for the 3DS confirmed.
New zelda for the 3DS.
Monster Hunter 3G for 3DS confirmed for western release with online play.
On 360/PS3 i would like to see FF versus 13 renamed as FFXV confirmed and Kingdom hearts 3 confirmed (all as multiplatform). Sonic Adventure 3 or Sonic Heroes 2 would also be welcome for me.
New tales of game for the 3DS would be cool aswell but i dont think theres any chance of such an announcement on E3. Its more of a TGS thing.