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Jexy said:
Superman Prime if we're going mainstream. He's basically Superman but kryptonite doesn't affect him. Dr. Manhattan if we spread it out, although he's really only in one series (Watchmen). For those interested, Superman fought Hulk multiple times in crossovers that DC and Marvel did and Superman won. Keep in mind, Hulk isn't Hulk all the time. When he turns back to Banner, a bullet can kill him or just anything that would kill normal people. Superman is always Superman. Hulk also doesn't possess the powers that Superman has. Which puts Hulk in at a slightly weaker Doomsday, since Doomsday is always Doomsday. No weakness of turning into a mortal. (The monster that 'killed' Superman, aka best selling comic and graphic novel of all time).

But Superman Prime is a villian.   Unless i've missed something in recent comics.