MGS4 is a solid bet (no pun intended).
Killzone 2 remains a wildcard to me it has to REALLY prove itself.
Resistance 2 will definitely repeat its predecesors succes though in both the states and Europe.
FFXIII... no question about it.
Resident Evil 5 will push consoles... in Japan though, untill the PS3 gains firm ground in Europe I can't say with certainty - US seems like a lost cause even though it still will bring a good bunch of copies sold.
Little big Planet shows promise, and judging by the developers behind it they're hellbent on making it a huge succes so Im gonna go and say that "it will".
Haze... will have an impact in Europe, FPS are a pretty popular genre here.
God of War III needs to be seen before I can determine its potential, the hardcore fans will definitely buy it, but I have to see if it has more reach than that.
Gran Turismo will definitely kick a good bunch of consoles out in the blue... I dont GT5:p will do much though.
....I want to see some of the games that will be revealed at GDC, which I believe will have a substantial impact.