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Genjuro said:

It's in the eye of the observer.

For me american gaming is mostly irrelevant, I dislike flat uninspiring, generic and primitive gaming content and that counts for most of the american companies you listed, thats of course my personal opinion but if you talk about relevance in a total capital driven and badly regressed (creativity wise) "economy" you are probably right.

If I had to list some "relevant" gaming companies for my terms (games I really enjoyed in the last couple years and companies that are really noteworthy or "relevant" to me), i would list:

From Software, CD Project, Atlus, Capcom, Quantic Dreams and Nintendo.

Quantic Dream is french ;)