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Dark_Lord_2008 said:
Mass effect 3 should sell well in its opening week and temporarily boost XBox 360 and PS3 system sales.
Mass Effect 3 first week sales on XBox 360 over 1 million sales first week. ltd sales around 3 million.
Mass Effect 3 sales on PS3 around 300k first week. ltd sales around 1.5 million.


http://www.mcvuk.com/news/read/mass-effect-3-pre-orders-smash-targets/091840

Given how well it's done in terms of preorders, it's very possible that it could hit seriously high sales. 5 million combined would be out of this world, though, and I don't expect it will go that high.