Like you, I also demoed the PS-Vita. I overall, I thought the buttons were kinda small, but that they were still manageable. My biggest disappointment was probably the screen. I'm a big advocate of OLED and seeing it for the first time on the Vita was pretty disappointing. The black levels (which are suppose to be the biggest drawing point for OLED) seem to have a "washed-out" look to it. The display also didn't seem to be too bright, but I couldn't find out how to raise and lower the brightness, so it could have just been in a low setting. Also, you can obviously tell games like Gravity Rush and Uncharted weren't running in the Vita's native resolution. It looked kinda low-res, which was a disappointment.
Overall, I gotta be honest and say that I wasn't that impressed with the Vita. Sure, the graphics on an almost PS/360 level are nice, but I just don't find more value seeing them on a handheld than I do on my TV. The games are going to be what is most important, and since I don't play handhelds that much, there has to be more games released that will make me want to own a Vita. Currently, Uncharted alone hasn't made me want to spend $250 to play just one game. Obviously there is great potential for amazing games, but I need to wait to see those game in order to commit to purchasing a Vita.
I don't know why people tell me to get a life. I'm a gamer, I have lots of lives!