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It might have started as a knee jerk reaction to 'clean up' but It's all about control now.
Legal drug abuse kills more people nowadays then illegal drug use.

"More people in the US die from an overdose of medications such as oxycontin than they do of heroin. Over one third of some 35-40,000 poisoning deaths each year in the US involve prescription opioids."
http://www.guardian.co.uk/society/datablog/2011/nov/30/prescription-drug-use-survey

Government / pharmaceutical industry already wins on prescription drugs. Legalizing marihuana would undercut their profits.

Some drugs should never be legalized like heroin but I find it strange that alcohol is regarded as 'safe' while a lot of far less damaging substances for yourself and others are heavily prosecuted.
http://www.saferchoice.org/content/view/24/53/