Alas, my post on Super Smash Bros Melee (my number 3) ended up as somewhat of a rant against tourneyfags (a word i hesitate to use, though let it be known that it reflects in no negative way upon homosexuals), which is the only point that has soured my memory of that game, but since tourneyfaggotry played only a small role in how i enjoyed that game (it was only one or two of my friends who were of the "no items Fox only final destination" persuasion) it still holds its pre-eminence in my list
Monster Hunter: pissing me off since 2010.