Xbox 360/PC/PS3/Wii
1. Deus Ex Human Revolution
2. Skyrim and Oblivion (Elder Scrolls series if you are counting both as one)
3. Mass Effect series
4. Fallout 3 (to a MUCH lesser extent New Vegas as well)
5. Alice Madness Returns
6. L.A. Noire
7. Red Dead Redemption
8. Portal Series
9. Assassin's Creed 1 and 2 (if you must count it as a series go right ahead)
10. Bioshock (only the first one)
Not a single exclusive on the list ... really can't accuse me of console bias (maybe HD consoles I guess).